The knockout of SMYD3 delayed cyst growth and improved kidney function in postnatal day 7 (P7) DKO kidneys compared to age-matched PKD1 single knockout (PKD1 SKO) kidneys, as shown by the decrease in the kidney-weight-to-body-weight (KW/BW) ratio (Figure 2B,C), cystic index (Figure 2D,E), and blood urea nitrogen (BUN) levels (Figure 2F). This evidence concerns the gene PKD1 and cyst.