The correlation between aberrant centrosome amplification and upregulation of cell cycle effectors in SMYD3-overexpressed mIMCD3 cells, and the upregulation of SMYD3 in PKD1 mutant renal epithelial cells and tissues, suggests that a SMYD3-mediated mechanism may be involved in the centrosome amplification phenotype observed in ADPKD kidneys. Here, SMYD3 is linked to autosomal dominant polycystic kidney disease.