Another study showed that in patients with neuroblastoma, the AA genotype and the A allele of the Gly/Arg388 variant were more frequent than in controls, demonstrating that regulation of FGFR4 has slower degradation than the Gly388 receptor in neuroblastoma cells and reduced internalization into multi-vesicular bodies [50]. This evidence concerns the gene FGFR4 and neuroblastoma.