Another possible mechanism for the beneficial effects of statins on autoimmune myocarditis involves the inhibition of major histocompatibility complex class II (MHC-II) expression on endothelial cells, monocytes, and macrophages through inhibition of the class II transactivator IV (CIITA) promoter, leading to a decrease in MHC-II-mediated T cell activation [32]. This evidence concerns the gene CIITA and autoimmune myocarditis.