Furthermore, Kamiya et al. [55] also demonstrated that without BK or OME, the production rates of NO and PGI2 were 0.042 ± 0.032 μM/106 cells and 784.46 ± 212.45 pg/mL/106 cells, respectively, showing that both NO and PGI2 were produced at steady rates. This evidence concerns the gene KNG1 and otitis media with effusion.