TP53 and colorectal carcinoma: These observations are confirmed by the study by Massari et al., who in the colon cancer cell line WiDr (identical with HT-29 cells), expressing a mutant p53 (mp53), showed that the SMS analogue has pro-apoptotic and antiproliferative effects, which can enhance the effect of 5-FU on human CRC cells expressing mp53 [135].