Selective inhibition of human telomerase activity, participation in the translocation of Ku86 from the cytoplasm to the cell nucleus, regulation of the Ku70/86 heterodimer and interaction between Ku70, nCLU and Bax may also contribute to modulating apoptosis and blocking the growth of CRC cells and via the SST system. Here, XRCC5 is linked to colorectal carcinoma.