Recently, amiloride-sensitive sodium reabsorption, independent of any ENaC subunit, was demonstrated using a truncated variant of acid-sensing ion channel 2b (ASIC2b) in association with ASIC2a in a corticosteroid-clamped PAN-induced nephrotic-syndrome rat model (CC-PAN rat model). Here, ASIC2 is linked to polyarteritis nodosa.