On the contrary, hesperetin attenuated DR in rats through downregulation of IL-1β, IL-6, NFκB, and TNF-α in the retinal tissue homogenates, which confirmed the inhibitory effects of hesperetin on inflammatory burdens and matches previous evidence that illustrated hesperetin ameliorated the inflammation in diabetic nephropathy in rats [61]. The gene discussed is TNF; the disease is diabetic kidney disease.