CASP3 and Hypernatremia: However, under the OGD/R condition, caspase-3 expression was significantly higher in the 0.9% CH3COONa and in different combinations, i.e., 3:1 and 2:1, as compared to the control, suggesting that reperfusion of OGD-subjected microglial cells with hypernatremia can lead to cell death via a caspase-3 dependent pathway.