Second, when compared between ACE2 and Dp16;ACE2 mice, the same five top pathways were activated in ACE2 mice on day 6 p.i. and in Dp16;ACE2 mice on day 4 p.i., thus indicating that Dp16;ACE2 mice respond to virus infection more rapidly (Figure 5C). The gene discussed is ACE2; the disease is viral infectious disease.