Exosomal SAA3 is associated with the induction of STAT3 signaling [107] and anti-inflammatory M2 polarization [108]; FGL-1 binds to and activates LAG-3, a regulatory protein on T cells, for immunotherapy [109,110] and anti-inflammation [111]; ORM2, also known as AGP2, can inhibit neutrophil migration in diabetic mice with sepsis [112]; NGP, specific for mouse neutrophils [113], exhibits sequence similarity to an antimicrobial protein CAMP [113] and demonstrates inflammation modulation [113,114]. The gene discussed is FGL1; the disease is Sepsis.