The Global Antiphospholipid Syndrome Score (GAPSS) is used to estimate the risk of recurrent thrombosis, which takes into account the traditional risk factors such as hypertension and hyperlipidemia, as well as the presence of antiphospholipid antibodies (LA, aCL IgG and/or IgM, aß2GPI IgG and/or IgM and anti-phosphatidylserine/prothrombin complex IgG or IgM). The gene discussed is CD40LG; the disease is antiphospholipid syndrome.