Both eyes were examined using OCT in: (i) the APP/PS1 model in the studies conducted by Harper et al. (2020) [42] and Georgevsky et al. (2019) [41]; (ii) the 3xTg-AD model in the works of Ferreira et al., Guimarães et al., Chiquita et al., and Batista et al. model [44,47,48,49]; and (iii) the TgCRND8 model analysed by Buccarello et al. [35]. This evidence concerns the gene APP and Alzheimer disease.