The most frequent PTM among all galectins was phosphorylation and the galectin that was targeted the most by PTM was Gal-1, as shown in Figure 4A. When analyzing the mutational profile of each of the galectins in HNSCC (Supplementary Table S2 and Figure 4B), it was possible to observe that the most mutated galectins in HNSCC were Gal-3BP, Gal-12, Gal-1, and Gal-4. The gene discussed is LGALS4; the disease is head and neck squamous cell carcinoma.