When studying the immune subtypes of HNSCC, we found that Gal-1, Gal-3, Gal-3BP, Gal-4, and Gal-9 were mostly expressed in the IFN-γ Dominant (C2) immune subtype and to a lesser extent in the Wound Healing (C1) immune subtype, as shown in Table 2. The gene discussed is LGALS3; the disease is head and neck squamous cell carcinoma.