The two CLL groups can be further subdivided based on the expression of the proteins ZAP70 and CD38, the mutation status of TP53, SF3B1, ATM, and NOTCH1, additional mutations, chromosomal aberrations (deletions of chromosomes 13q, 17p, and 11q as well as trisomy 12), and various important signaling pathways (for a review see [1]). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.