Cell signals mediated by the oestrogen receptors: extracellular signal-regulated kinase (ERK1/2), protein kinase B (Akt/PKB) and nuclear factor kappa B (NFκB); and by human epidermal growth factor type-2 receptors: mitogen-activated protein kinase (MAPK) cascade signalling, phosphatidylinositol polyphosphate (PIP), are connected with the progression and development of breast cancer [17]. The gene discussed is NFKB1; the disease is breast cancer.