In contrast, lidocaine treatment increases the anti-inflammatory gene expression of Interferon Regulatory Factor 6 (Irf6), Kinase Insert Domain Receptor (Kdr), Programmed Cell Death 1 Ligand 2 (Pcdc1lg2), Breast Cancer Anti-Estrogen Resistance 3 (bcar3), Matrix Metalloproteinase 12 (mmp12), Von Willebrand Factor (vwf), Suppressor of Cytokine Signaling 2 (socs2), Integrin Subunit Beta 3 (Itgb3), Interleukin 10 (Il10), Purinergic Receptor P2Y1 (P2ry1), and Aquaporin 9 (Aqp9) (Figure 2C). Here, MMP12 is linked to breast carcinoma.