Treatment of benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 and prostate cancer cell lines LNCaP and DU145 with 100 μM and 500 μM OLE for 72 h determined a reduction in cell viability, probably as a consequence of the reduction in Akt phosphorylation levels, with cells showing signs of necrosis for the highest of the two tested OLE doses. The gene discussed is AKT1; the disease is benign prostatic hyperplasia.