In an in vivo model of tumor xenograft (triple negative MDA-MB-231 cell line) in BALB/c OlaHsd-foxn1 mice, peritoneally injected 50 mg/kg OLE for 4 weeks exhibited a synergistic effect with doxorubicin on inhibition of tumor growth and induction of apoptosis [40]. The gene discussed is FOXN1; the disease is neoplasm.