PDRG1 and nasopharyngeal carcinoma: In nasopharyngeal cancer cell line HNE1 and HONE1, 200 μM OLE enhanced cell radiosensitivity in vitro and in vivo after injection in BALB/C nude mice, with a mechanism involving OLE-dependent removal of HIF-1α hypoxic repression exerted at miR-519d promoter region, upregulation of miR-519d, and miR-519d targeting of DNA damage-regulated protein 1 (PDRG1) [278].