KL and diabetes mellitus: After adjustment for age, sex, BMI, duration of diabetes, and HbA1c, urinary Klotho was significantly associated with UACR ≥ 3.0 mg/mmol in patients with T2D (OR = 0.96, 95% CI 0.93–0.9996 for each 10 ng/mmol of urinary Klotho, p = 0.048, Table 4).