The clinical relevance of measuring and quantifying peripheral blood, as liquid biopsy, B-cell frequency and B-cell subsets distribution as well as circulating pro-/anti-inflammatory cytokines (BSF-2(IL-6), CSIF:TGIF(IL-10), and the BSF-2(IL-6) to CSIF:TGIF(IL-10) ratio) may play an important role in POAG pathogenesis and might help as potential molecular markers to assess POAG disease progression and severity. The gene discussed is IL6; the disease is open-angle glaucoma.