C4A and Anxiety: Research indicates a notable link between SLE-related psychiatric symptoms such as depression and anxiety and the presence of specific markers like anti-cardiolipin (ACL), anti-beta2 glycoprotein I antibodies (Anti B2 GP1), lupus anticoagulant (LA), intercellular adhesion molecule (I CAM-1), diminished C4, and anti-ribosomal P antibodies (Anti RIB P).