Moreover, dietary genistein had the potential to directly alleviate the inflammatory response by modulating the expression of inflammatory factors such as NF-кB, IL-8, IL-1β, and IFN-γ through the involvement of PPARδ and T-cell factor 3 (TCF3) in laying hens induced fatty liver [15]. This evidence concerns the gene CXCL8 and Hepatic steatosis.