STAT1 and metabolic dysfunction-associated steatohepatitis: Therefore, we imitated the occurrence of NASH in transgender women in a rat model by providing a high-fat high-fructose (HFHF) diet with orchidectomy (ORX) and evaluating whether genistein, a phytoestrogen, and standard sex hormone supplement could improve NASH through the modification of all types of peroxisome proliferator-activated receptors (PPARs; α, δ, γ) and signal transducer and activator of transcription 1 (STAT1) signaling pathway.