Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, are capable of inhibiting the expression of MMPs, in particular MMP-2, and plasminogen activator-urokinase (PAI) in metastatic lung cancer and melanoma cells (A549, B16-F1) [231,232]. Here, MMP2 is linked to melanoma.