Quercetin treatment (80 μM) also suppressed the phosphorylation of c-Met and its downstream effectors including Gab1 (GRB2-associated-binding protein 1), FAK and PAK (p21-activated kinases) in the human medulloblastoma cell line DAOY, human hepatoma HepG2 and melanoma A375 and A2058 cell lines [177]. Here, PTK2 is linked to melanoma.