In the tumor context, one mechanism by which integrins promote invasiveness is the activation of several genes involved in the EMT, which is marked by a switch between the expression of the epithelial cadherin (Epithelial cadherin, E-cadherin) and the mesenchymal isoform (Neural cadherin, N-cadherin) and by the expression of particular integrins such as the αV integrin [17]. Here, CDH2 is linked to neoplasm.