PTK2 and malignant colon neoplasm: Further, Chen et al. evaluated the effects of curcumin in human colon cancer cell lines from the NCI-60 panel (including HCT-116, HT-29, HCT-15, HCC-2998, Colo205, Km-12 and SW-620 cells), both in vitro and in SCID mice, and found that this polyphenol inhibits FAK phosphorylation and decreases CD24 expression [161].