Similarly, caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) caused the inhibition of AP-1 and c-fos nuclear factor activity as well as the inhibition of PMA-induced FAK, ERK and MEK phosphorylation in human gastric and breast carcinoma cell lines (25 μM) [205]. This evidence concerns the gene EPHB2 and breast carcinoma.