MMP9 and neoplasm: Specifically, in evaluating the action of curcumin on the invasive capacity of tumor cell lines, Lin et al. and Thiyagarajan et al. demonstrated how even low concentrations of curcumin are already able to inhibit the enzymatic action of MMP-2 and MMP-9 in a mouse–rat hybrid retina ganglion cell line (N18) [199,200].