SHPK and obesity due to melanocortin 4 receptor deficiency: For example, ShK, a potassium-channel toxin isolated from the venom of the sea anemone Stichodactyla helianthus, was the source for “Dalazatide” (previously known as “ShK-186”), a synthetic peptide that is a specific inhibitor of the voltage-gated Kv1.3 potassium channel and has been subjected to trials for the treatment and management of autoimmune diseases such as psoriasis [10], rheumatoid arthritis [11], obesity and insulin resistance [12].