Metabolic pathways (ko01100, 49 genes), cell cycle (ko04110, 33 genes), PI3K-Akt signaling pathway (ko04151, 21 genes), cellular senescence (ko04218, 20 genes), and transcriptional misregulation in cancer (ko05202, 20 genes) were the pathways with the most genes. The gene discussed is AKT1; the disease is cancer.