It has been proposed as a potential tumor suppressor and therapeutic target for several H. sapiens cancers [15], and due to the DKK3 gene being the subject of increasing studies, a gene possessing a sequence homology with DKK3 has been identified, namely DKKL1 (Dickkopf-like 1), a distant member of the DKK family that is a secreted glycoprotein with a potential role in spermatogenesis [16]. This evidence concerns the gene DKKL1 and cancer.