However, each 1 ng/mL increase in GH serum concentration was associated with a 12.7% increase in the HOMA for insulin resistance (HOMA-IR), and IGF-1 concentration was positively correlated with C-peptide concentration in Swedish Elkhounds, showing that GH also exerts a strong insulin resistance effect during diestrus [75]. Here, GH1 is linked to Insulin resistance.