INS and Insulin resistance: Despite the absence of fasting glycemia differences among bitches with pyometra or other estrus cycle phases [15], the severe increase in fasting insulinemia during pyometra allowed a clear demonstration of the insulin resistance status, employing insulin sensitivity indexes such as the II and AI: GR (both ~2-fold higher compared to diestrus), as well as HOMA-B and HOMA-R (both ~3-fold higher compared to diestrus).