Mdivi-1 did not significantly alter the expression of total DRP1 but effectively alleviated the expression of phosphorylated DRP1 and reversed the reductions in OPA1, MFF, Mifn1, and Mifn2 in CRC cells induced by the combined IR and NCTD treatment (Figure 7C–E). Here, OPA1 is linked to colorectal carcinoma.