In contrast, the observed negative correlations between AOPPs and HDL2-apoA-I in the HVs and HDL4-apoA-I in patients with MS (but no correlations between AOPPs and the corresponding subclasses of HDL-apoA-II) suggest associations of AOPPs with the HDL particles that contain only apoA-I. Here, APOA1 is linked to myeloid sarcoma.