In comparison to the HFD control, C/Sal suppressed activation of the phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), rapamycin (mTOR) nuclear factor kappa B (NF-κB), and Wnt pathways, activated 5’ adenosine monophosphate (AMP)-activated protein kinase (AMPK), attenuated abnormal proliferation of the colonic mucosa, and reduced tumor multiplicity and burden [116]. This evidence concerns the gene NFKB1 and neoplasm.