EHW also reduced TNF-α levels and restored glutathione in a dextran sulfate sodium-induced colitis model [14], inhibited proinflammatory cytokines such as IL-1β, IL-6, and COX-2 by suppressing NF-κB and activating the NF-E2-related factor 2 signaling pathway in an LPS-induced infection model [16], decreased levels of IL-1β and IL-33, and reduced mast cell infiltration in an atopic dermatitis model [15]. This evidence concerns the gene NFKB1 and colitis.