In contrast, disrupting the SP-NK1R axis through either the genetic deletion of the Tac1 gene, the pharmacological blockade of NK1R using L703606, or the combination of these two approaches attenuated the decreases in the expression of Nrf2 (p < 0.01) and Gpx4 (p < 0.001) in the lungs in mice with CLP-surgery-induced sepsis. The gene discussed is TACR1; the disease is Sepsis.