Suppressing the SP-NK1R axis through either the deletion of the Tac1 gene (p < 0.05), the pharmacological blockade of NK1R using L703606 (p < 0.05), or the combination of these two approaches (p < 0.01) attenuated the decrease in the expression of Nrf2 in the liver in mice with CLP-surgery-induced sepsis. This evidence concerns the gene TACR1 and Sepsis.