Suppressing the SP-NK1R axis through either the genetic deletion of the Tac1 gene (p < 0.001), the pharmacological blockade of NK1R using L703606 (p < 0.001), or the combination of these two methods (p < 0.001) significantly attenuated sepsis-associated hypothermia in mice four hours, six hours, and eight hours after CLP surgery (p < 0.01). This evidence concerns the gene TACR1 and Sepsis.