In contrast, suppressing the SP-NK1R axis through either the genetic deletion of the Tac1 gene (p < 0.05), the pharmacological blockade of NK1R using L703606 (p < 0.05), or the combination of these two approaches (p < 0.01) attenuated the decrease in the expression of Gpx4 in the liver in the Tac1+/+ mice following CLP-surgery-induced sepsis. Here, TAC1 is linked to Sepsis.