TACR1 and Sepsis: Suppressing the SP-NK1R signalling by either the genetic deletion of the Tac1 gene (p < 0.001), the pharmacological blockade of NK1R using L703606 (p < 0.001), or the combination of these two methods (p < 0.001) significantly mitigated these abnormalities in mice with CLP-surgery-induced sepsis, leading to better a physical condition and lower sepsis severity scores (Table 2).