Suppressing the SP-NK1R axis through either the genetic deletion of the Tac1 gene (p < 0.001), the pharmacological blockade of NK1R using L703606 (p < 0.001), or the combination of these two approaches (p < 0.001) attenuated the decrease in the concentration of GSH in the liver and lungs in mice with CLP-surgery-induced sepsis. The gene discussed is TAC1; the disease is Sepsis.