Notably, there was no significant difference in the lung injury scores (p > 0.05) and the lung W/D ratios (p > 0.05) of mice following CLP-surgery-induced sepsis who underwent any of the following manipulations: the genetic deletion of the Tac1 gene, the pharmacological blockade of NK1R, or the combination of these two approaches. The gene discussed is TACR1; the disease is Sepsis.