TAC1 and Sepsis: In accordance with the change in the expressions of Nrf2 and Gpx4 in the liver, the Tac1+/+ mice with CLP-surgery-induced sepsis also showed significantly lower expressions of Nrf2 (p < 0.001) and Gpx4 (p < 0.001) in the lungs in comparison with the sham-operated controls, as depicted in Figure 7.