In contrast, suppressing SP-NK1R signalling through either the deletion of the Tac1 gene (p < 0.01), the pharmacological blockade of NK1R using L703606 (p < 0.001), or the combination of these two approaches (p < 0.001) attenuated the increase in the concentration of iron in the liver in mice with CLP-surgery-induced sepsis. The gene discussed is TACR1; the disease is Sepsis.