Xi Chen et al. recently demonstrated that ATF3 activation mediated by sirtuin1 (SIRT1) deacetylase decreased SLC7A11 and GPX4 expression in glioma cells treated with the GPX4 inhibitor RSL3, causing ferroptosis, associated with intracellular ferrous iron increase and lipid peroxidation [308]. The gene discussed is GPX4; the disease is central nervous system cancer.