This enzyme has been implicated in protective processes because of its catalytic activity toward 15-HpETE-PEs: indeed, naturally occurring mutations in its gene (PNPLA9) are associated with neurodegenerative diseases like neurodegeneration with brain iron accumulation (NBIA) class [181] and Parkinson disease 14, autosomal recessive (PARK14) [182]. This evidence concerns the gene PLA2G6 and Parkinson disease.