In fact, the knockdown of p65 by siRNA enhanced the NRF2-mediated activation of HO-1, GPX2, and NQO1 genes in hepatoma HepG2 cells, whereas co-transfection of HO-1(ARE), GPX2(ARE), or NQO1(ARE)-Luc reporters with either NF-κB, p65, or IKKβ expressing vectors inhibited ARE-driven expression [339]. The gene discussed is RELA; the disease is hepatocellular carcinoma.