Recently, Takahashi et al., by using three-dimensional (3D) cancer spheroid models from lung cancer cell lines (A549 and H1347 bearing hyperactivated NRF2), demonstrated that NRF2 prevents lipid peroxidation through reducing ROS levels in inner spheroid cells, which are more susceptible to ferroptosis, as proven by the same authors [294]. Here, NFE2L2 is linked to lung cancer.