Another metabolic gene regulated by p53 and promoting ferroptosis is spermidine/spermine N1-acetyltransferase 1 (SAT1), a key enzyme of polyamine catabolism that was induced by nutlin-3 or doxorubicin treatment in cancer cell lines expressing wild-type p53 (U2OS, MCF7, and A375) but not in the p53-null cell line H1299 [358]. This evidence concerns the gene TP53 and cancer.