NFE2L2 and neoplasm: It was demonstrated that NRF2-dependent transcriptional activation of genes involved in heme (i.e., HO-1), iron (i.e., FTH1), and ROS metabolism (i.e., NQO1) could protect against ferroptosis and that NRF2 inhibition potentiated the sensitivity to ferroptosis in vitro and in tumor xenograft models [289].