Indeed, additional experiments revealed that ATF4-dependent tumor-promoting effects are mediated by transcriptional targeting the glutamate antiporter xCT/SLC7A11, and the knockdown of ATF4 increases the ferroptosis cell death induced by different ferroptosis agents, including sorafenib, erastin, and RSL3, associated with lipid peroxidation accumulation [299]. The gene discussed is ATF4; the disease is neoplasm.