SOCS1 and hepatocellular carcinoma: For example, suppressor of cytokine signaling 1 (SOCS1) mediates p53 phosphorylation at Ser15, leading to ferroptosis-related downregulation of SLC7A11 and upregulation of spermidine/spermine N1-acetyltransferase 1 (SAT1) [352,353], while the attenuation of p53 phosphorylation at Ser46 in hepatocellular carcinoma HepG2, mediated by zinc finger protein 498 (ZNF498), lowered ROS production and GSL2 expression, and raised GSH production, with a consequent increase of cell survival and p53-mediated ferroptosis inhibition [354].