ATF2 and gastric cancer: Further experiments in GC cells demonstrated that ATF2 knockdown inhibited malignant phenotypes and potentiated ferroptosis induced by sorafenib, a protein kinase inhibitor drug, causing endoplasmic reticulum stress, GSH depletion, and iron-dependent lipid radical accumulation, while overexpression of ATF2 reduced sorafenib-induced ferroptosis sensitivity.