A recent work revealed that oncogenic activation of the PI3K-AKT-mTOR, frequent in human cancer, is causally related to ferroptosis resistance primarily sustained by lipogenesis mediated by mTORC1 activation with consequent induction of sterol regulatory element-binding protein 1 (SREBP1), a transcription factor that in turn increases SCD1 expression, in part by increased NRF2 [279]. The gene discussed is SREBF1; the disease is cancer.