SLC7A11 and cancer: Cancer cells induce the cystine transporter SLC7A11 to increase the cellular levels of GSH [6,7,8], upregulate the hexose monophosphate shunt and malic enzyme to increase the production of NADPH [9,10,11] and increase the expression of GPX4 [12], which collectively detoxify hydroxyl and lipid alkoxyl radicals to protect the cells from ferroptosis despite the presence of excessive iron within the cells.