On the other hand, polymorphisms in genes coding for arachidonate 5-lipoxygenase (ALOX5) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) were not found to be associated with the increased risk of carotid plaques in a large cohort of Chinese T2DM patients [42]. This evidence concerns the gene ALOX5 and type 2 diabetes mellitus.