NOS3 and coronary artery disorder: However, when SOD2 Val16Ala was included in the composite 5 polymorphic gene score, along with GCLM C-588T, NOS3 G894T, CYBA C242T, and MPO G-463A, carriers of ≥8 pro-oxidant alleles had a significantly increased risk for coronary heart disease (CHD) compared to the carriers of <8 pro-oxidant alleles; this association was found to be significant with or without adjustment for patients clinical characteristics [39].