For example, in ulcerative colitis patients, IgG interacts with gut macrophages expressing Fc-gamma receptor, which results in the induction of the NLRP3 inflammasome—a critical component of the innate immune system—and reactive oxygen species (which, in turn, stimulate the pro-inflammatory cytokine IL1b production [99,100]). This evidence concerns the gene IL1B and ulcerative colitis.