The FUS protein, together with SOD1 and C9orf72, which carry known ALS-associated mutations, are more detrimental, and induce a stronger inflammatory response when expressed in glia cells than in neuronal cells, pointing to an important role of resident macrophages in ALS neurodegeneration [154,155,156,157]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.