CBS and Hyperglycemia: In accordance with the results from the HRECs, in the Cbs+/+ diabetic mice, the retinal SAM levels and Dnmts activity were elevated by three-fold and 50%, respectively, and Dnmts activation was significantly higher in the hyperhomocystinemic–hyperglycemia model, with an over six-fold increase in SAM and >250% increase in Dnmts activity in the retina from the Cbs+/− diabetic mice (Figure 7a,b).