Interestingly, in turn, type-I IFN was shown to induce cellular pyroptosis, apoptosis, and necroptosis governed by ZBP1 [16,33], and it was found that IFN-β treatment potentiated PANoptosis in macrophages during viral infection, which was relied on ZBP1 and specifically its Zα2 domain [34], indicating that there is a feedback loop between PANoptosis and type-I IFN. The gene discussed is IFNB1; the disease is viral infectious disease.