In recent studies, novel inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), the CRP-to-lymphocyte ratio (CLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII), have been acknowledged as surrogate markers of systemic inflammation, and they have been valuable indicators for the diagnosis and prognosis of diverse infectious diseases, including cancer [7,8,9], heart disease [10,11], acute respiratory distress syndrome (ARDS) [12], and COVID 2019 [13]. The gene discussed is CRP; the disease is heart disorder.