BDNF and in situ carcinoma: Using BDNF at baseline as the dependent variable, and MS type (RRMS, CIS or HC), MS diagnosis (PwMS or HC), treatment (IFN-β1a or TER), background (urban or rural), sex (male or female) and season (cold or warm) as fixed factors for a two-way ANOVA (Univariate Analysis of Variance), it returned a corrected model with a p = 0.722, suggesting that none of the fixed factors or their interactions contributed to the values of BDNF at baseline significantly.