APP and Alzheimer disease: To further determine whether DDB-elicited suppression of APP amyloidogenic processing improves Aβ burden in 3 × Tg-AD mice brains, we performed immunohistochemistry staining to observe the Aβ peptide load by MOAB-2 antibody (Figure 3C), which recognizes the unaggregated, oligomeric and fibrillar form of Aβ.