In addition, these mice showed significant work memory deficits in a spatial object location task and the Morris water maze test, whereas the memory impairment and cognitive dysfunction in the 3 × Tg-AD mice were remarkably alleviated within seven months of continuous DDB administration, consistent with alleviating the effects of DNLAs on cognitive and behavioral impairment in 3 × Tg-AD mice (Figure 1 and Figure 2), in SAMP8 mice [13,24], in APP/PS1 mice [11], and in lipopolysaccharide- and Aβ-induced AD animal models [10,15]. This evidence concerns the gene PSEN1 and memory impairment.