Additionally, it was found that YY1 is negatively regulated by corticotropin-releasing hormone receptor-2 (CRHR2)/Urocortin-2 (Ucn2) signaling, which can result in transcriptional de-repression of Fas and can resensitize the tumor to anti-Fas antibody-mediated apoptosis [82]. This evidence concerns the gene CRHR2 and neoplasm.