The TME holds several immunosuppressive cells and factors including cancer-associated fibroblasts (CAFs) [13,14], myeloid-derived suppressor cells (MDSCs) [15,16], tumor-associated macrophages (TAMs) [17,18], T regulatory cells (Tregs) [19,20], and other additional suppressive factors such as transforming growth factor-β (TGF-β) [21,22], chemokines, cytokines [23,24], etc. Here, TGFB1 is linked to cancer.