Another study by Nuñez et al. showed differential positive predictive biomarkers for irAE: Ki67+ Treg cell expansion in malignant melanoma and CD8+CD38+Ki67+ T-cell expansion in NSCLC, while other cell populations were not predictive for the development of irAEs in both types of cancer [57]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.