HSPH1 and brain cancer: There were also two chaperones, LRP (MESD), a modulator of the Wingless/Integrated (Wnt) pathway, and the heat shock protein 105 kDa (HSPH1), a nucleotide-exchange factor for chaperones HSPA-1A and -1B; this was consistent with our previous finding that HSP90 alpha can discriminate MB from all other brain cancers, in a proteomic analysis of EVD CSF from children bearing various CNS tumors [19].