CD40 and neoplasm: Figure 4 highlights the inhibition observed for the groups locally treated with LIFE Biomaterial loaded with anti-CD40 monoclonal antibodies (mAbs) with/without one fraction of 6 Gy. Tumor growth was inhibited for both the treated/primary tumor and the untreated secondary tumor in both sets of studies shown in Figure 4b–e. Response in treatment groups without radiation highlights the fact, also seen in other studies, that anti-CD40 itself can cause immunogenic cell death and in situ vaccination [35,36].