A randomised study of autologous DCs co-cultured with CIKs plus IFNα vs. no adjuvant therapy in patients post-surgical resection for RCC demonstrated a reduction in recurrence and metastatic disease (p < 0.01), with increased CD4+/CD8+ ratios and reduced CD4+/CD25high populations [62]. This evidence concerns the gene CD8A and metastatic neoplasm.