Comparison of mRNA expression levels in LGG tumor (509 patients evaluated in the Xena portal) versus normal tissues showed significant upregulation (p < 0.0001) in tumors for ligands TGFB1/2, interferon-gamma activated receptors, and the corresponding downstream signaling molecules (IFNGR1, IFNGR2, STAT1, IRF1, and IRF5), and markers for tumor-associated markers (TAMs) MSR1 and CD86 exhibited very low expression levels in normal tissue (<0 log2 TPM equivalent to TPM value of 1) but experienced a significant increase in expression levels in tumor tissue. Here, IRF5 is linked to neoplasm.