The differential expression of TGF signaling genes, including ACVR1, PPP2R1B, GDF7, RBX1, and MAPK3, has been linked to their role in tumor progression and metastasis in the current study, as they were overexpressed in advanced disease in terms of tumor size and metastatic cervical lymph nodes samples. The gene discussed is ACVR1; the disease is neoplasm.