Briefly, well-established pancreatic cancer susceptibility genes include BRCA2, ATM, BRCA1, PALB2, CDKN2A, STK11, PRSS1, SPINK1, and the mismatch repair genes (MLH1, PMS2, MSH2, and MSH6), as summarized in Table 2. This evidence concerns the gene PRSS1 and pancreatic neoplasm.