Briefly, well-established pancreatic cancer susceptibility genes include BRCA2, ATM, BRCA1, PALB2, CDKN2A, STK11, PRSS1, SPINK1, and the mismatch repair genes (MLH1, PMS2, MSH2, and MSH6), as summarized in Table 2. The gene discussed is SPINK1; the disease is pancreatic neoplasm.