Briefly, well-established pancreatic cancer susceptibility genes include BRCA2, ATM, BRCA1, PALB2, CDKN2A, STK11, PRSS1, SPINK1, and the mismatch repair genes (MLH1, PMS2, MSH2, and MSH6), as summarized in Table 2. The gene discussed is PRSS1; the disease is familial pancreatic carcinoma.