PIP4K2B and head and neck squamous cell carcinoma: While we have not observed the significant difference in Overall Survival (OS) and Progression-Free Survival (PFS) in patient samples with low vs. high levels of PIP4K2B mRNA (Supplementary Figure S1D,E), the analysis of the mRNA level of PIP4K2B in HNSCC tissues and normal tissues showed an increased level of PIP4K2B in tumor samples (Supplementary Figure S1F).