Since PIP4K2B affects PI3K and mTORC1 signaling [18,27,28,29], and as we recently showed that NSD1 depletion decreases Akt/mTORC1 signaling [7], we investigated whether mTORC1 regulation could be PIP4K2B-dependent in head and neck cancer. Here, PIP4K2B is linked to head and neck cancer.